AACR 2026

Cross Platform

Abstract # Authors Affiliation Title / Session Products
1201 Yunhe Liu, Idania Carolina Lubo Julio, Wei Lu, Alejandra G. Serrano, Jean R. Clemenceau, Amber Famiglietti, Karen Colbert, Yibo Dai, Yang Liu, Jun Wang, Jeremy L. Davis, Mingyao Li, Paul F. Mansfield, Tae Hyun Hwang, Luisa M. Solis-Soto, Linghua Wang Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX | Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX | Department of Surgery, Vanderbilt University Medical Center, Nashville, TN | National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD | Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX | BioChemistry&Molecular Biology, University of Maryland School of Medicine, Baltimore, MD | University of Pennsylvania, Philadelphia, PA | Vice President, Acute Care Services, UT MD Anderson Cancer Ctr., Houston, TX | Department of Translational Molecular Pathology, the university of MD Anderson cancer center, Houston, TX
Spatial 3D and multi-omics mapping of diffuse gastric cancer evolution from preinvasive to invasive lesions in CDH1 mutation carriers
4/19/2026 2:00:00 PM | Spatial Proteomics and Transcriptomics 1
Xenium; Visium; CosMx; GeoMx; G4X
5524 Mary Goldman, Brian Craft, Cally Lin, Jingchun Zhu, David Haussler UC Santa Cruz Genomics Institute, Santa Cruz, CA | Stanford University, San Francisco, CA | Investigator/Distinguished Professor, Ctr. For Bio. Sci. & Eng., UC Santa Cruz, Santa Cruz, CA
Visualization and analysis of cancer genomics data using UCSC Xena
4/21/2026 2:00:00 PM | New Software Tools for Data Analysis
Xenium; Visium; Chromium; CosMx; MerFISH
1476 Steven Yan, Limin Jiang, Yan Guo University of Miami Miller School of Medicine, Miami, FL | University of Miami, Miami, FL
Improve spatial transcriptomic data with integrated hybrid transformer and graph convolutional networks
4/20/2026 9:00:00 AM | Integrative Computational Approaches 1
Xenium; Visium; CosMx
3444 Wesley V. Wilson, MacLean P. Nasrallah, Nakial Cross, Yael A. Day, Vanessa Gonzalez, Rachel M. Leskowitz, Amy Marshall, Julie K. Jadlowsky, Gabriela Plesa, Donald L. Siegel, Elizabeth O. Hexner, Joseph A. Fraietta, Carl H. June, Stephen J. Bagley, Donald O’Rourke, Zev Binder, Andrew J. Rech Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada | Penn Medicine, Philadelphia, PA | Perelman School of Medicine Univ. of Pennsylvania, Philadelphia, PA | CCI, Penn Medicine, Philadelphia, PA | University of Pennsylvania, Philadelphia, PA | Program Director of Translational Research, Abramson Family Cancer Research Inst, University of Pennsylvania, Philadelphia, PA
Spatial profiling of recurrent glioblastoma in a Phase I clinical trial reveals favorable immune remodeling induced by intracerebroventricular CAR T therapy
4/20/2026 2:00:00 PM | Microenvironmental Determinants of Therapy Response and Resistance 1
Visium; CosMx; GeoMx
6576 Chih-Hung Chung, Han-Hsun Yu, Muh-Hwa Yang National Yang Ming Chiao Tung University, Taipei, Taiwan
Integrative spatial transcriptomics reveals EMT-driven immune regulatory programs underlying metastasis in HNSCC
4/21/2026 2:00:00 PM | Inflammation, Immunity, and Cancer
Xenium; Visium; GeoMx
6895 Yufeng He, Yanping Zhao, Rui Zhang, Heli Yang, Zhaode Bu, Yuan Luo, Deng Pan, Zexian Zeng Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China | Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China | Center of Gastrointestinal Cancer, Peking University Cancer Hospital & Institute, Peking University, Beijing, China | Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL | Tsinghua-Peking Center for Life Sciences, Department of Basic Medical Sciences, Tsinghua University, Beijing, China
DISSECT integrates cytological images and spatial transcriptomics for cell segmentation
4/22/2026 9:00:00 AM | New Algorithms and Computational Methods
Xenium; Visium; CosMx
1205 Junyan Liu, Md Tauhidul Islam, Lei Xing Stanford University, Palo Alto, CA
Trajectory-aware spatial transcriptomics deconvolution via image representation of RNA-seq data
4/19/2026 2:00:00 PM | Spatial Proteomics and Transcriptomics 1
Xenium; Visium
1210 Kazutaka Otsuji, Tomo Osako, Yoko Takahashi, Chikako Shibata, Sumito Saeki, Asumi Iesato, Tetsuo Noda, Kengo Takeuchi, Takayuki Ueno, Reo Maruyama NEXT-Ganken Program, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan | Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan | Breast Oncology Center, Cancer Institute Hospital of JFCR, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan | Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan | Director's room, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
Integrated spatial and single-cell profiling uncovers a pre-existing, treatment-resistant subclone that drives early local relapse in luminal breast cancer
4/19/2026 2:00:00 PM | Spatial Proteomics and Transcriptomics 1
Xenium; Visium
1419 Bohyeon Yu, Emanuele Filiberto Rosatti, Jangham Jung, Abhinav Jain, Joanna Phillips, Aaron Antonio Diaz Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA | Department of Cellular, Computational and Integrative Biology, University of Trento, Trentino, Italy
Integrated spatial and genetic lineage tracing uncovers cell state plasticity underlying recurrence in group3 and group4 medulloblastoma
4/20/2026 9:00:00 AM | Application of Bioinformatics to Cancer Biology 2
Xenium; Visium
1487 Raymond Yan, Brian Falkenstein, A. Burak Tosun, Filippo Pullara, S. Chakra Chennubhotla PredxBio, Inc., Pittsburgh, PA | PredxBio, Inc. / University of Pittsburgh, Pittsburgh, PA
Spatial microdomains from histology reveal multi-omic biomarkers for enhanced idiopathic pulmonary fibrosis diagnosis
4/20/2026 9:00:00 AM | Integrative Computational Approaches 1
Xenium; Visium
2253 Fushun Chen, Lorena Isabel Gomez, Tieling Zhou, Yuejiang Liu, Inti C. Tarifa Reischle, Sujuan Yang, Manvi Sharma, ,Jiping Feng, Jaafar Hadi, Fuduan Peng, Yibo Dai, Mhenaz Hossain, Ratna Veeramachaneni, Ansam Sinjab, Sean Anderson, Dhrishit Mangrolia, Deborah Rodriguez, Nadim Ajami, Jennifer Wargo, Adel El-Naggar, Roberto Rangel, Nadarajah Vigneswaran, Linghua Wang, Jeffrey N. Myers, Humam Kadara UT MD Anderson Cancer Center, Houston, TX | UT Health School of Dentistry, Houston, TX
Multimodal and multikingdom spatial transcriptomics identify bacterial niches implicated in oral cancer development
4/20/2026 9:00:00 AM | Tumorigenesis and Early Microenvironmental Trajectories
Xenium; Visium
2255 Yibo Dai, Fuduan Peng, Ansam Sinjab, Yunhe Liu, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Jianlong Liao, Guangsheng Pei, Yang Liu, Jiahui Jiang, Kyung Serk Cho, Kai Yu, Jiping Feng, Zahraa Rahal, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Avrum Spira, Steven M. Dubinett, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Stephen G. Swisher, Mingyao Li, Junya Fujimoto, Ignacio Wistuba, Jared K. Burks, Kadir Caner Akdemir, Hind Rafei, Katayoun Rezvani, Jeffrey N. Myers, Humam Kadara, Linghua Wang UT MD Anderson Cancer Center, Houston, TX | Kobe University Hospital, Kobe, Japan | Juntendo University Graduate School of Medicine, Tokyo, Japan | Lung Cancer Initiative at Johnson and Johnson, Boston, MA | UCLA David Geffen School of Medicine, Los Angeles, CA | University of Pennsylvania, Philadelphia, PA | Hiroshima University Hospital, Hiroshima, Japan | Moffitt Cancer Center & Research Institute, Tampa, FL
Spatial transcriptomics reveals evolving tumor microenvironmental archetype along the lung premalignancy-adenocarcinoma continuum
4/20/2026 9:00:00 AM | Tumorigenesis and Early Microenvironmental Trajectories
Xenium; Visium
2259 Siyuan He, Aatish Thennavan, Runmin Wei, Shanshan Bai, Jianzhuo Li, Chante Bethell, Emi Sei, Mitchell Rao, Tapsi Kumar, Chenling Tang, Ivan Marin, Jessica Montalvan, Chandandeep Nagi, Bora Lim, Savitri Krishnamurthy, Alastair Thompson, Nicholas E. Navin UT MD Anderson Cancer Center, Houston, TX | Baylor College of Medicine, Houston, TX | Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, TX
Reprogramming of the stromal and immune microenvironment in preinvasive breast cancer
4/20/2026 9:00:00 AM | Tumorigenesis and Early Microenvironmental Trajectories
Xenium; Visium
2272 Akifumi Mochizuki, Ayako Suzuki, Kouya Shiraishi, Masahiro Torasawa, Takayuki Honda, Susumu Kirimura, Yasunari Miyazaki, Kenichi Okubo, Syuzo Kaneko, Yukihiro Yoshida, Shun-ichi Watanabe, Masahiro Tsuboi, Genichiro Ishii, Issei Imoto, Ryuji Hamamoto, Yasushi Yatabe, Yutaka Suzuki, Takashi Kohno Department of Respiratory Medicine, Institute of Science Tokyo, Tokyo, Japan | Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan | National Cancer Center Research Institute, Tokyo, Japan | Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan | Division of Pathology, Institute of Science Tokyo, Tokyo, Japan | Department of Thoracic Surgery, Institute of Science Tokyo, Tokyo, Japan | Division of Medical AI Research and Development, National Cancer Center Research Institute, Tokyo, Japan | Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan | Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan | Department of Pathology and Clinical laboratories, National Cancer Center Hospital East, Kashiwa, Japan | Dept. of Human Genetics, Inst. of Health Biosciences, Aichi Cancer Center Research Institute, Nagoya, Japan | Associate Professor, National Cancer Center Japan, Tokyo, Japan | Chief, Dept. of Pathology & Molec. Diagnostics, National Cancer Center, Nagoya, Japan
Dichotomous immunogenetic landscape of lung adenocarcinoma associated with usual interstitial pneumonia
4/20/2026 9:00:00 AM | Tumorigenesis and Early Microenvironmental Trajectories
Xenium; Visium
2298 Rhitajit Sarkar, Shilpa Thakur, Gus Fridell, Elijah Edmondson, Sonam Kumari, Joanna KLUBO-GWIEZDZINSKA Metabolic Diseases Branch, NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD | National Institutes of Health, Bethesda, MD | Johns Hopkins University, Baltimore, MD | National Institutes of Health, Reston, VA
Spatial immune profiling reveals varying tumor microenvironments in papillary thyroid microcarcinoma
4/20/2026 9:00:00 AM | Hormone Receptor Signaling and Therapeutic Targeting
GeoMx; nCounter
2708 Robert F. Gruener, Weijie Zhang, Lilin Wang, Adam M. Lee, R. Stephanie Huang University of Minnesota, College of Pharmacy, Minneapolis, MN | University of Minnesota, Minneapolis, MN | Asst. Professor, Dept. of Medicine, University of Minnesota, Minneapolis, MN
Revealing fibroblast-mediated impacts to therapy response through spatially resolved drug response prediction in lung cancer
4/20/2026 2:00:00 PM | Integration of Clinical and Research Data
Xenium; CosMx
2754 Haenara Shin, Dongjoo Lee, Jeongbin Park, Hongyoon Choi Portrai, Inc., Seoul, Korea, Republic of
VGL: Vision-Gene-Language multimodal LLM integrating histopathology and gene expression for cell type classification in lung cancer
4/20/2026 2:00:00 PM | Large Language Models in the Clinic
Xenium; Visium
3951 Assya Legrini, Tengyu Zhang, Mari-Claire McGuigan, Colin Wood, Luke McNickle, Claire Kennedy-Dietrich, Ghazal Latifi, Yoana Doncheva, Josefina Vasquez, Hannah Morgan, Pamela McCall, Michail Doukas, Joanne Edwards, Nigel Jamieson Univ. of Glasgow, Glasgow, United Kingdom | Glasgow Tissue Research Facility, Univ. of Glasgow, Glasgow, United Kingdom | Erasmus MC, Rotterdam, Netherlands
Spatial mapping of B7-H3 mediated cellular plasticity in treatment naive pancreatic cancer
4/20/2026 2:00:00 PM | Spatial Proteomics and Transcriptomics 2
CosMx; GeoMx
3973 Tim Schunk, Tim Mandelkow, Shida Xiong, Jonas Raedler, Rodler Severin, Philipp Nuhn, Anne Letsch, Marion van Macklenbergh, Jan Weitkamp, Jakob Kohler, Arne Christians, Oliver Braubach, Steve Lott, Micaela Mathiak, Gavin Gordon, Björn Konukiewitz, Christoph Rocken, Niclas Christian Blessin Universitätsklinikum Schleswig-Holstein, Kiel, Germany | Bruker Spatial Biology | Canopy Biosciences, St. Louis, CA | Bruker Spatial Biology, St. Louis, CA | Professor, Dept. of Pathology, Christian-Albrechts-University, Kiel, Germany
A framework for antibody validation via spatial proteo-transcriptomics using the CellScape platform
4/20/2026 2:00:00 PM | Spatial Proteomics and Transcriptomics 2
CosMx; CellScape
4021 Y.-C. Kao, S. X. Tan, X. Tan, H. Oey, K. J. Lee, T. Vallius, R. Pelletier, A. Causer, C. Zhou, D. Smit, J. O'Neill, A. Xiong, B. O'Brien, A. Collins, P. K. Sorger, H. Soyer, K. Khosrotehrani, Q. Nguyen, M. S. Stark; Frazer Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Australia, QIMR Berghofer Medical Research Institute, Brisbane, Australia, Harvard Medical School, Brookline, MA, Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, Institute for Molecular Bioscience, the University of Queensland, Brisbane, Australia, QIMR Medical Research Institute, Queensland, Australia, Brisbane, Australia, Sullivan Nicolaides Pathology, Brisbane, Australia, Harvard Medical School, Winchester, MA
Precision diagnostics for early melanoma detection using spatial biology and AI guided image analysis
4/20/2026 4:05:00 PM | Biomarkers That Change Management: Predicting Therapy Benefit, Progression, and Metastatic Risk
Xenium; Visium
4795 Michael Emilio Patrick, Wei Yang, Liang Zhang, Isabel Lee, Stefan-Laural Rogers, Shanshan He, Christina Bailey, John Lyssand, Joseph M. Beechem Bruker Spatial Biology, Seattle, WA
Investigating HER2+ tumor cell motility and angiogenesis in FFPE breast cancer in space and at scale with CosMx and nCounter multiomics
4/21/2026 9:00:00 AM | Angiogenesis
CosMx; nCounter
4945 Ji Hye Choi, Yeong Hak Bang, Kyung Yeon Han, Woong-Yang Park Sungkyunkwan University, Seoul, Korea, Republic of | University of Ulsan College of Medicine, Seoul | Translational Genomics Center, Seoul, Korea, Republic of | GENINUS, Seoul, Korea, Republic of
Distinct colorectal cancer tumor cell subtypes revealed by single-cell and spatial transcriptomics
4/21/2026 9:00:00 AM | Spatial Niches and Functional Boundaries within the Tumor Microenvironment 1
Xenium; Visium
4951 Sanha Hwang Seoul National University, Seoul, Korea, Republic of
Unraveling the role of APOE/APOC1/SPP1/TREM2‑positive lipid‑Associated macrophages in destructive venous invasion and metastasis of colorectal cancer
4/21/2026 9:00:00 AM | Spatial Niches and Functional Boundaries within the Tumor Microenvironment 1
Xenium; GeoMx
4960 Bryan Bell, Cedric Uytingco, Alec Barrett, Bryant Ngo, Jonathan Sakkos, Diksha Kool, Wanxin Wang, Melissa del Rosario, Christina Chang, Christina Fan, Andrew Farmer Takara Bio USA, San Jose, CA
Cross-platform comparison of spatial transcriptomics technologies in an FFPE lung squamous cell carcinoma sample
4/21/2026 9:00:00 AM | Spatial Niches and Functional Boundaries within the Tumor Microenvironment 1
Xenium; Visium
4984 Joseph Zenga, Musaddiq Awan, Fumou Sun, Stuart J. Wong, Abdullah Memon, Tyce Kearl, Ean Norenberg, Margaret L. Hoang, Joseph M. Beechem, Eric Hobbs, Ashley Heck, Rachel Liu, Daniel McGuire, Erin Piazza, Peiman Hematti, Heather Himburg Medical College of Wisconsin, Milwaukee, WI | Bruker Spatial Biology, Seattle, WA | Bruker Spatial Biology, Piedmont, CA | Bruker Cellular Analysis, Emeryville, CA
Dissociative, spatial, and functional single-cell profiling reveals antigen-driven exhaustion and chemotactic failure of tumor-reactive T cells in HPV-negative HNSCC
4/21/2026 9:00:00 AM | Tumor-Immune Crosstalk
CosMx; Beacon
5499 Xiyu Peng, James Smithy, Mohammad Yosofvand, Caroline Kostrzewa, Fiona Ehrich, MaryLena Bleile, Jasme Lee, Michael A. Postow, Margaret K. Callahan, Katherine Panageas, Ronglai Shen Texas A&M University, College Station, TX | Memorial Sloan Kettering Cancer Center, New York, NY | Univ. of Connecticut School of Medicine, Farmington, CT
SpatialTopic exploring tumor ecosystem in 3D multiplexed imaging of melanoma
4/21/2026 2:00:00 PM | New Software Tools for Data Analysis
Xenium; CosMx
5519 Junming Shi, Md Tauhidul Islam Stanford University School of Medicine, Stanford, CA
SOMaC: An interpretable and generalizable framework for integrating and clustering multimodal spatial omics to resolve cell states and immune niches in cancer
4/21/2026 2:00:00 PM | New Software Tools for Data Analysis
Xenium; Visium
6113 Yufei Wang, Jae-Won Cho, Yasmin Nabil Laimon, Wenxin Xu, Kun Huang, Aseman Bagheri Sheshdeh, Nithyassree Murugan, Hsien-Chi Yuan, Jon Wee, David Alexander Braun, Toni K. Choueiri, Catherine J. Wu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco Dana-Farber Cancer Institute, Boston, MA | Brigham and Women's Hospital, Boston, MA | Yale School of Medicine, New Haven, CT | Associate Professor, Dana-Farber Cancer Institute, Boston, MA
ccRCC lung metastases harbor cancer associated fibroblast lymphocyte exclusion sites that form a confined TME as revealed by single cell and spatial multi-omics
4/21/2026 2:00:00 PM | Metastasis and Organ-Specific Microenvironmental Evolution
Xenium; CosMx
6159 Ping Xu, Yuehui Zhao, Yun Yan, Rui Ye, Chenling Tang, Emi Sei, Shanshan Bai, Tuan Tran, Cole Ruoff, Christine Ly, Keyi Zhu, Miao Zhang, Bila A. Siddiqui, Sumit K. Subudhi, Paul Corn, Christopher J. Logothetis, Patricia Troncoso, Amado J. Zurita-Saavedra, Nicholas Navin Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX | Department of Pathology, UT MD Anderson Cancer Center, Houston, TX | Department of Genitourinary Medical Oncology, UT MD Anderson Cancer Center, Houston, TX
Co-evolution of cancer cells and their microenvironment of primary and lymph node metastatic prostate cancer under androgen deprivation therapy
4/21/2026 2:00:00 PM | Metastatic Niches and Microenvironment
Xenium; Visium
6188 Yun Yan, Yiyun Lin, Tapsi Kumar, Shanshan Bai, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Min Hu, Mitchell Rao, Anna Casasent, Elizabeth Ravenberg, Gaiane Margishvili Rauch, Alyson Clayborn, Debu Tripathy, Alastair Thompson, Bora Lim, Lei Huo, Lei Huo, Stacy Moulder, Clinton Yam, Nicholas E. Navin UT MD Anderson Cancer Center, Houston, TX | Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, TX
Decoding the archetypes and ecotypes of triple-negative breast cancer in responses to chemotherapy
4/21/2026 2:00:00 PM | Spatial Niches and Functional Boundaries within the Tumor Microenvironment 2
Xenium; Visium
6212 Julia Louw, Kenan Zhang, Anna Corcoran, Elizabeth Owens, Jodie Jepson, Jose R. Conejo-Garcia, David M. Ashley, Kanish Mirchia, David R. Raleigh, Mustafa Khasraw Duke University, Durham, NC | Duke University School of Medicine, Durham, NC | Duke University Medical Center, Durham, NC | UCSF, San Francisco, CA | University of California San Francisco, San Francisco, CA | Duke Cancer Institute, Durham, NC
Spatial immune and vascular remodeling defines recurrence in oligodendroglioma
4/21/2026 2:00:00 PM | Spatial Niches and Functional Boundaries within the Tumor Microenvironment 2
Xenium; Visium
6470 Nakial C. W. Cross, Yael A. Day, Sonia Ndeupen, Vanessa E. Gonzalez, Zhen Miao, Sam I. Kim, Rachel M. Leskowitz, Amy Marshall, Julie K. Jadlowsky, Gabriela Plesa, Donald L. Siegel, Elizabeth O. Hexner, Jakub Svoboda, Stephen J. Schuster, Nancy R. Zhang, Joseph A. Fraietta, Andrew J. Rech, Carl H. June Perelman School of Medicine Univ. of Pennsylvania, Philadelphia, PA | Statistics & Data Analysis, Wharton School Univ. of Pennsylvania, Philadelphia, PA
Spatial remodeling of the tumor microenvironment by IL-18-armored CD19 CAR T cells is associated with durable remission in relapsed or refractory lymphoma
4/21/2026 2:00:00 PM | Clinical Correlates of Immunotherapy
CosMx; GeoMx
6549 Yi Cui, Moumita Nath, Michael Emilio Patrick, Claire Williams, Daniel McGuire, Jobin K. Paul, Kowshik Jaganathan, Biswajit Das, Mohit Malhotra, Shanshan He, Joseph M. Beechem, Satish Sankaran Bruker Spatial Biology, Seattle, WA | Farcast Biosciences India, Bengaluru, India
Integrating functional biosignatures and same-cell spatial multiomics to predict synergistic benefit of combination checkpoint therapy in head and neck cancer
4/21/2026 2:00:00 PM | Immune Checkpoint Blockade
CosMx; nCounter
6591 Daniel Jimenez-Sanchez, Matthew H. Ingalls, Sanghamithra korukonda, Brian J. Lane, Isabella Marie Peshek, Patrick Danaher, Prajan Divakar, Oliver Braubach Bruker Spatial Biology, St. Louis, MO | Bruker Spatial Biology, Seattle, WA | Division of Gastroenterology, Northwestern University, Chicago, IL
Cross platform same slide multi-omics reveals Treg heterogeneity and links to spatial niche variability in pre-cancerous colonic inflammation
4/21/2026 2:00:00 PM | Inflammation, Immunity, and Cancer
CosMx; CellScape
6667 Cindy Pamela Ulloa Guerrero, Michele Bortolomeazzi, Pooja Sant, Laura Schütze, Laura Giese, Denise Keitel, Julia Boehl, Robin Reschke, Jan-Philipp Mallm Single-cell Open Lab, DKFZ German Cancer Research Center, Heidelberg, Germany | Max-Eder Research Group Reschke, University Hospital Heidelberg, Heidelberg, Germany
Integrated spatial transcriptomics and proteomics workflows for high-resolution multiomics analysis
4/21/2026 2:00:00 PM | Spatial Proteomics and Transcriptomics 3
Xenium; Visium
6788 B. Zhu, M. Aminu, Y. Tian, S.-W. Lu, O. Shi, W. Lu, H. Chen, H. Li, Z. Wei, M. B. Nilsson, L. Solis Soto, F. P. Andrew, D. L. Gibbons, J. V. Heymach, C. Cheng, J. Wu, J. Zhang; UT MD Anderson Cancer Center, Houston, TX, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, TX
Spatial single-cell analysis reveals stage-dependent mechanisms of anti-IL-1β therapy in lung adenocarcinoma
4/21/2026 3:20:00 PM | Inflammation and Immunity in Cancer Progression
Xenium; Visium
6853 Xiao Wang, Nan Zhang, Chi Zhang, Sha Cao Indiana University, Bloomington, IN | Fudan University, Shanghai, China | Knight Cancer Institute, Oregon Health & Science University, Portland, OR | Biomedical Engineering, Oregon Health and Science University, Portland, OR
A segmentation-free method for modeling high-resolution spatial transcriptomics at the molecule level
4/22/2026 9:00:00 AM | Mathematical Modeling and Statistical Methods
Xenium; Visium
6914 Xinyu Hu, Fengwei Zhan, Lixia C. Wu, Jose Gonzalez, Chuhanwen Sun, Rachel Ofer, Tyler Tran, Michael Verzi, Jiekun Yang Department of Genetics, Rutgers University, New Brunswick, NJ | Quantitative Biomedicine Program, Rutgers University, New Brunswick, NJ
STCS: Spatial transcriptomics cell segmentation outperforms existing methods on multiple slides
4/22/2026 9:00:00 AM | New Algorithms and Computational Methods
Xenium; Visium
7235 Yi Cui, Huy Nguyen, Andrea Floris, David King, Serdar Tulu, David Castillo, Shanshan He, Shyamtanu Chattoraj, Jude Dunne, Mirko Corselli, John Lyssand, Joseph M. Beechem Bruker Spatial Biology, Seattle, WA | Bruker Spatial Genomics, San Jose, CA
Integrated spatial multiomic profiling of 3D genome architecture and transcriptome-wide gene expression in breast cancer models
4/22/2026 9:00:00 AM | Chromatin Architecture and Regulatory Landscapes
CosMx; PaintScape
LB237 Wei Zhao, Aaron Rozeboom, Phuc H. Hoang, Tam-Anh Tran, Maria Teresa Landi National Cancer Inst. Div. of Cancer Epidemiology & Genetics, Bethesda, MD | Cancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD
High-resolution spatial transcriptomics identifies unique spatial programs in lung adenocarcinoma from never smokers
4/20/2026 2:00:00 PM | Late-Breaking Research: Tumor Biology 1
Xenium; Visium